Data Providers · Flatiron Health
used Flatiron's Enhanced Data Mart for real-world/external-control analysis supporting Canadian HTA reimbursement approval of a BRAF V600E–targeted NSCLC treatment
Flatiron Health is a Roche-owned company supplying EHR-derived oncology real-world data, captured at the source through its own OncoEMR software.
This sits in the Data Providers stage of the AI use-case lifecycle: Named examples from the real-world-data, claims and competitive-intelligence providers pharma AI systems are trained on, benchmarked against, or run inside of.
Source
Published by Flatiron Health on its own site — read the original case study on resources.flatiron.com ↗
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- 01used Flatiron's Clinical Genomics Database (with Foundation Medicine) for a natural-history study of 743 KRAS G12C patients supporting Lumakras FDA approval
- 02used Flatiron's Spotlight database for benchmark/indirect-comparison analyses supporting the mobocertinib (Exkivity, EGFR Exon20ins) regulatory/HTA submission
- 03used de-identified Flatiron EHR data to study unmet need in mantle cell lymphoma post-cBTKi therapy, supporting FDA accelerated approval of pirtobrutinib
- 04used Flatiron real-world data to compare overall survival of niraparib maintenance therapy vs. active surveillance in recurrent ovarian cancer
- 05used EHR-derived RWD to identify low-LVEF metastatic breast cancer patients on Kadcyla (T-DM1), fulfilling a post-approval regulatory commitment and securing label updates in the US/EU/Canada
- 06partnered with Flatiron to design a prospective clinico-genomic study using routine-care data for advanced lung cancer patients