Charles River used Synthace DOE software to miniaturise and transfer a SARS-CoV-2 protease assay to 1536-well plates.

One-factor-at-a-time work had failed to give a robust assay across sites and automation platforms. Charles River ran a single Synthace design of experiments covering 12 factors over 768 runs in 1536-well format. The page reports a z' of 0.82, two reagents removed from the buffer, and consistent transfer across labs, operators and dispensers.

Synthace is a software company whose design-of-experiments and lab automation platform helps biology teams develop and transfer assays faster.

This sits in the Design & Stress-Test stage of the AI use-case lifecycle: Named examples from the tools pharma teams use to scope, prototype and benchmark an AI use case before committing to build it — data-catalog, sandbox and evaluation platforms.