Pfizer applies systems pharmacology modelling in MATLAB and SimBiology to reduce phase II attrition.
High phase II attrition wastes R&D spend. Pfizer models drug pathways in SimBiology, running sensitivity analyses to choose targets and dosing before trials. The page describes an siRNA project modelled with 26 species and 64 parameters that exposed insufficient enzyme inhibition and avoided unnecessary lab and clinical spend, without giving overall figures.
MathWorks makes MATLAB and Simulink, used by pharma and medical device teams for modelling, machine learning and regulated device software development
This sits in the Design & Stress-Test stage of the AI use-case lifecycle: Named examples from the tools pharma teams use to scope, prototype and benchmark an AI use case before committing to build it — data-catalog, sandbox and evaluation platforms.
Published by MathWorks on its own site — read the original case study on mathworks.com ↗
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