A top-20 pharma improved the thermostability of a S. aureus vaccine antigen in a single Cradle round.

Rational design would have needed about seven rounds over 3.5-7 months for a 2.5 C melting temperature gain. Scientists ran one zero-shot round of 96 candidates with Cradle. The page reports a +2.50 C increase in melting temperature, 7x faster than rational design, with several variants between +1.5 C and +2.5 C.

Cradle is an AI protein engineering software company whose platform designs and optimizes proteins, antibodies, enzymes and peptides for biopharma and industry.

This sits in the Design & Stress-Test stage of the AI use-case lifecycle: Named examples from the tools pharma teams use to scope, prototype and benchmark an AI use case before committing to build it — data-catalog, sandbox and evaluation platforms.