A biomanufacturing company nearly tripled P450 enzyme activity in three Cradle rounds after plateauing.

After 10 rounds and 1,200 P450 variants, rational design had hit diminishing returns. Cradle's platform was trained on the company's historical data and proposed mutations combined with human expertise over three rounds of 96-192 sequences. The page reports activity nearly tripled in 3 rounds, a 4x faster rate of improvement, and activity more than doubled in the first two rounds.

Cradle is an AI protein engineering software company whose platform designs and optimizes proteins, antibodies, enzymes and peptides for biopharma and industry.

This sits in the Design & Stress-Test stage of the AI use-case lifecycle: Named examples from the tools pharma teams use to scope, prototype and benchmark an AI use case before committing to build it — data-catalog, sandbox and evaluation platforms.